Welcome to PALS!
The Psychopathology and Allostatic load across the Life Span (PALS) network is a network of international academic centers that have come together to transform windows of vulnerability to mental and physical disorders into windows of neuroscientific advancement with diagnostic and therapeutic implications.
To view the full mission statement, click here. To learn more about the aims and goals of PALS, the different academic sites, and current events and projects, please explore the tabs located in the sidebar.
Recent Publications
October 2018 - Congratulations to Drs. Robakis, Rasgon, Nasca, and McEwen, as well as Katie Watson, for "Early Life Adversity Blunts Responses to Pioglitazone in Depressed, Overweight Adults," wich was recently published online in European Psychiatry.
"Early life adversity is associated with both metabolic impairment and depression in adulthood, as well as in poorer responses to antidepressant medications. It is not yet known whether individual differences in sensitivity to antidiabetic medications could also be related to early life adversity."
Click here to read the full paper!
November 2018 - Congratulations to Drs. Frangou, Felice, Rasgon, McIntyre, and McEwen for "Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes" which was published in the Journal of Psychiatric Research.
Fig.1 (right) Gene Expression in the Dorsolateral Prefrontal Cortex
Mean standardized expression values of insulin and dopamine signaling genes in the dorsolateral prefrontal cortex, according to group (HC vs MI) and BMI.
Announcements:
July 2018: Dr. McIntosh is fundraising for MQ, a British charity that supports research both in the US and the UK. Please help him reach his fundraising target by donating at this link.
Recent Events:
August 2018: We are excited to announce that, under Dr. Nemeroff's leadership, Dell Med is launching the Institute for Early Life Adversity Research as part of the Mulva Clinic for the Neurosciences.
Meet the Members!
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