Recent Publications

Insulin resistance doubles risk of major depressive disorder, Stanford study finds


Published online September 2021 in Stanford Medicine News

Insulin resistance: Genetic associations with depression and cognition in population based cohorts

Authors: Sophia Frangou, Masoud Shirali, Mark J. Adams, David M. Howard, Jude Gibson, Lynsey S. Hall, Blair H. Smith, Sandosh Padmanabhan, Alison D. Murray, David J. Porteous, Chris S. Haley, Ian J. Deary, Toni-Kim Clarke, Andrew M. McIntosh

Published online June 2019 in Experimental Neurology

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Childhood trauma and insulin resistance in patients suffering from depressive disorders

Authors: Carla Nasca, Kathleen Watson-Lin, Benedetta Bigio, Thalia K. Robakis, Alison Myoraku, Tonita E. Wroolie, Bruce S. McEwen, Natalie Rasgon

Published online March 2019 in Experimental Neurology

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Early life adversity blunts responses to pioglitazone in depressed, overweight adults

Authors: Thalia K. Robakis, Kathleen Watson-Lin, Tonita E. Wroolie, Alison Myoraku, Carla Nasca, Benedetta Bigio, Bruce McEwen, Natalie L. Rasgon

Published online January 2019 in European Psychiatry

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Brain and behavioral correlates of insulin resistance in youth with depression and obesity

Authors: Manpreet K. Singh⁠, Sara M. Leslie, Mary Melissa Packer, Yevgeniya V. Zaiko, Owen R. Phillips, Elizabeth Weisman, Danielle Wall, Booil Jo, Natalie L. Rasgon

Accepted on March 26, 2018 in Hormones and Behavior

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Multivariate Associations Among Behavioral, Clinical, and Multimodal Imaging Phenotypes in Patients With Psychosis

Authors: Dominik A. Moser, Gaelle E. Doucet, Won Hee Lee,  Alexander Rasgon, Hannah Krinsky, Evan Leibu, Alex Ing, Gunter Schumann, Natalie Rasgon, Sophia Frangou 

Published online March 7, 2018 in JAMA Psychiatry

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Depression and obesity: evidence of shared biological mechanisms

Authors: Yuri Milaneschi, W. Kyle Simmons, Elisabeth F. C. van Rossum, Brenda WJH Penninx

Published online February 16, 2018 in Molecular Psychiatry

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Determinants of cognitive function in adults with Type 2 Diabetes Mellitus: A meta-analysis

Authors: Mansur, R., Rasgon, N., Yena, L., Zhou, A., Rosenblat, J., Bruins, R.,...McIntyre, R

Published online February 30, 2018 in  Annals of Clinical Psychiatry

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An Integrated Brain-Behavior Model for Working Memory

Authors: D A Moser, G E Doucet, A Ing, D Dima, G Schumann, R M Bilder, S Frangou

Published online December 5, 2017 in Molecular Psychiatry

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Insulin Resistance, an unmasked culprit in depressive disorder: Promises for intervention

Authors: Kathleen Watson, Carla Nasca, Linn Aasly, Bruce McEwen, Natalie Rasgon

Published online: November 26, 2017 in Neuropharmacology

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Roles of Inflammation and Depression in the Development of Gestational Diabetes

Authors: Thalia Robakis, Linn Aasly, Katherine Williams, Claire Clark, Natalie Rasgon

Published online October 28, 2017 in Current Behavioral Neuroscience Reports 

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Treatment with a GLP-1R agonist over four weeks promotes weight loss-moderated changes in frontal-striatal brain structures in individuals with mood disorders

Authors: Mansur RB, Zugman A, Ahmed J, Cha DS,Subramaniapillai M, Lee Y, Lovshin J, Lee JG, Lee J, Drobinin V, Newport J, Brietzke E, Reininghaus EZ, Sim K, Vinbery B, Rasgon N, Hajek T, McIntyre RS.

Published September 1, 2017 in European Neuropsychopharmacology

Telomere length and bipolar disorder

Authors: Powell T, Danai D, Frangou S, Breen G

Accepted: June 2017 in Neuropsychopharmacology

Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus

Authors: Grillo CA, Pirolo GG, Junor L, Wilson SP, Mott DD, Wilson MA, Reagan LP

Published: February 2011 in Physiology and Behavior

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Memory Impairment in Obese Zucker Rats: An Investigation of Cognitive Function in an Animal Model of Insulin Resistance and Obesity

Authors: Winocur G, Greenwood CE, Piroli GG, Grillo CA, Reznikov LR, Reagan LP, McEwen BS 

Published: 2005 in Behavioral Neuroscience 

Memory Impairment in Obese Zucker Rats.p[...]
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Hippocampal insulin resistance and cognitive dysfunction

Authors: Geert JB and Reagan LP

Published: November 2015 in Nature

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity 

Authors: Grillo CA, Piroli GG, Lawrence RC, Wrighten SA, Green AJ, Wilson SP, Sakai RR, Kelly SJ, Wilson MA, Mott DD, Reagan LP

Published: 2015 in Diabetes

Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.

Authors: Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, Miller AH, Nemeroff CB

Published: August 2000 in JAMA Psychiatry

Influence of child abuse on adult depression: moderation by the corticotropic-releasing hormone receptor gene.

Authors: Bradly RG, Binder EB, Epstein MP, Tang Y, Nair HP, Liu W, Gillespie CF, Berg T, Evces M, Newport DJ, Stowe ZN, Heim CM, Nemeroff CB, Schwartz A, Cubells JF, Ressler KJ

Published: February 2008 in Archives of General Psychiatry

Differential functional connectivity within an emotion regulation neural network among individuals resilient and suspectible to the depressogenic effects of early life stress. 

Authors: Cisler JM, James GA, Tripathi S, Mletzko T, Heim C, Hu XP, Mayberg HS, Nemeroff CB, Kilts CD.

Published: March 2013 in Psychological Medicine


Cisler et al Cambridge 2012.pdf
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Metabolic syndrome, major depression, generalized anxiety disorder, and ten-year all-cause and cardiovascular mortality in middle aged and elderly patients.

Authors: Butnoriene J, Bunevicius A, Saudargiene A, Nemeroff CB, Norkus A, Ciceniene V, Bunevicius R. 

Published: 2015 in the International Journal of Cardiology

Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect

Authors: Nemeroff CB

Published: March 2, 2016 in Neuron

Childhood trauma predicts antidepressant response in adults with major depression: data from the randomized international study to predict optimized treatment for depression.

Authors: Williams LM, Debattista C, Duchemin AM, Schatzbergy AF, Nemeroff CB.

Published: May 3, 2016 in Translational Psychiatry

Elevated Body Mass Index is associated with increased integration and reduced cohesion of sensory-driven and internally-guided resting-state functional brain networks

Authors: Doucet GE, Rasgon N, McEwen BS, Micali N, Frangou S

Published: January 23, 2017 in Cerebral Cortex

The Brain and Body on Stress: Allostatic Load and Mechanisms for Depression and Dementia

Authors: McEwen BS, Rasgon N

Published: November 2013 in Perspectives on Psychological Science

Insulin Resistance: A Missing Link No More

Authors: Rasgon N, McEwen BS

Published: October 4, 2016 in Molecular Psychiatry


Adjuvant pioglitazone for unremitted depression: Clinical correlates of treatment response

Authors: Rasgon N, Wroolie T, Watson K, Robakis, T

Published: October 22, 2015 in Psychiatry Research

Adjuvant pioglitazone for unremitted dep[...]
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Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study

Authors: Rasgon N, Lin KW, Lin J, Epel E, and Blackburn E

Published: January 5 2016 in Translational Psychiatry

Telomere length as a predictor of respon[...]
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Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study

Authors: Mansur RB, Ahmed J, Cha DS, Woldeyohannes HO, Subramaniapillai M, Lovshin J, Lee JG, Lee JH, Brietzke E, Reininghaus EZ, Sim K, Vinberg M, Rasgon N, Hajek T, McIntyre RS

Published: January 1, 2017 in Journal of Affective Disorders

Liraglutide promotes improvements in obj[...]
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A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder

Authors: McIntyre RS, Soczynska JK, Woldeyohannes HO, Miranda A, Vaccarino A, MacQueen G, Lewis GF, Kennedy SH

Published: November, 2012 in Bipolar Disorders


randomized double blind intranasal insul[...]
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